Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

We provide an introduction to network theory, evidence to support a connection between molecular network structure and neuropsychiatric disease, and examples of how network approaches can expand our knowledge of the molecular bases of these diseases. Without systematic methods to derive their biological meanings and inter‐relatedness, the many molecular changes associated with neuropsychiatric disease, including genetic variants, gene expression changes, and protein differences, present an impenetrably complex set of findings. Network approaches can potentially help integrate and reconcile these findings, as (...) well as provide new insights into the molecular architecture of neuropsychiatric diseases. Network approaches to neuropsychiatric disease are still in their infancy, and we discuss what might be done to improve their prospects. (shrink)

Distributional semantic models (DSMs) are a primary method for distilling semantic information from corpora. However, a key question remains: What types of semantic relations among words do DSMs detect? Prior work typically has addressed this question using limited human data that are restricted to semantic similarity and/or general semantic relatedness. We tested eight DSMs that are popular in current cognitive and psycholinguistic research (positive pointwise mutual information; global vectors; and three variations each of Skip-gram and continuous bag of words (CBOW) (...) using word, context, and mean embeddings) on a theoretically motivated, rich set of semantic relations involving words from multiple syntactic classes and spanning the abstract–concrete continuum (19 sets of ratings). We found that, overall, the DSMs are best at capturing overall semantic similarity and also can capture verb–noun thematic role relations and noun–noun event-based relations that play important roles in sentence comprehension. Interestingly, Skip-gram and CBOW performed the best in terms of capturing similarity, whereas GloVe dominated the thematic role and event-based relations. We discuss the theoretical and practical implications of our results, make recommendations for users of these models, and demonstrate significant differences in model performance on event-based relations. (shrink)

This important handbook provides a comprehensive, authoritative review of achievement motivation and establishes the concept of competence as an organizing ...

Children are not simply molded by the environment; through constant inference and interpretation, they actively shape their own social world. This book is about that process. Elliot Turiel's work focuses on the development of moral judgment in children and adolescents and, more generally, on their evolving understanding of the conventions of social systems. His research suggests that social judgements are ordered, systematic, subtly discriminative, and related to behavior. His theory of the ways in which children generate social knowledge through (...) their social experiences will be of interest to a wide range of researchers and students in child development and education. (shrink)

Elliot R. Wolfson intervenes in the debate over Martin Heidegger and Nazism from a unique perspective, as a scholar of Jewish mysticism and philosophy who has been profoundly influenced by Heidegger's work. He reveals crucial aspects of Heidegger's thinking that betray an affinity with dimensions of Jewish thought.

Clear and distinct perception is the centrepiece of Descartes’s philosophy — it is the source of all certainty — but what does he mean by ‘clear’ and ‘distinct’? According to the prevailing approach, what it means for a perception to be clear is that its content has a certain objective property, like truth. I argue instead that clarity is at least partly a subjective, phenomenal quality whereby a content is presented as true to the perceiving subject. Clarity comes in degrees. (...) Any weak degree of clarity, available to the senses, can be merely subjective, since what it presents as true may not actually be true. But complete clarity, available to intellectual perception, has an objective dimension, since what it presents as true is always some truth, some bit of reality. Further, I argue that the other perceptual qualities that Descartes identifies — obscurity, confusion, and distinctness — are all defined in terms of clarity. Of particular note is the fact that distinctness is not a positive feature to be added to clarity: a distinct perception is just a completely clear perception. (shrink)

Descartes is widely portrayed as the arch proponent of “the epistemological transparency of thought” (or simply, “Transparency”). The most promising version of this view—Transparency-through-Introspection—says that introspecting (i.e., inwardly attending to) a thought guarantees certain knowledge of that thought. But Descartes rejects this view and provides numerous counterexamples to it. I argue that, instead, Descartes’s theory of self-knowledge is just an application of his general theory of knowledge. According to his general theory, certain knowledge is acquired only through clear and distinct (...) intellection. Thus, in his view, certain knowledge of one’s thoughts is acquired only through clear and distinct intellection of one’s thoughts. Introspection is a form of intellection and it can be clear and distinct. Ordinarily, however, introspection isn’t clear and distinct but is instead confused with dubitable perceptions of bodies. To make introspection clear and distinct, we need to “sharply separate” it from all perceptions of bodies by doubting all perceptions of bodies. Without such radical doubt, introspection remains confused and we lack certain knowledge not just of the specific features of our thoughts, but even of the minimal claim that a thought exists. Far from being the high priest of Transparency, Descartes is radically opposed to it. (shrink)

Metaethical expressivism faces the perennial objection that its commitment to non‐cognitivism about moral judgment renders the view revisionary of our ordinary moral thought. The standard response to this objection is to say that since the expressivist's theoretical commitments about the nature of moral judgment are independent of normative ethics, the view cannot be revisionary of normative ethics. This essay seeks to evaluate the standard response by exploring several senses of independence that expressivism might enjoy from normative ethics. I develop a (...) taxonomy on which, at least by the expressivist's own lights, normative ethics is not dependent on non‐cognitivism about moral judgment in a way that might render that claim itself normative ethical. The argument will require us to formulate a theory of moral subject matter according to the expressivist, a matter of independent interest. Although this discussion will essentially vindicate the standard response to the perennial objection, it will also highlight a major limitation thereof. This is that even for the expressivist, the taxonomic independence of non‐cognitivism about moral judgment from normative ethics does not guarantee its moral independence from normative ethics; that is, showing that non‐cognitivism about moral judgment is not a moral claim is not itself to show that it is not a morally relevant claim. I conclude by arguing that the question of moral dependence, usually discussed under the heading of objectivity, is ultimately first‐order moral rather than taxonomic, and so can only be resolved on first‐order moral grounds. (shrink)

There is a strong presumption that mental disorder injures a person's autonomy, understood as a set of capacities and as an ideal condition of agency which is worth striving for. However, recent multidimensional approaches to autonomy have revealed a greater diversity in ways of being autonomous than has previously been appreciated. This presumption, then, risks wrongly dismissing variant, neuro-atypical sorts of autonomy as non-autonomy. This is both an epistemic error, which impairs our understanding of autonomy as a phenomenon, and a (...) moral error, which withholds recognition and respect that autonomous agents are due. I argue that careful attention to the different 'shapes' of agent's autonomy reveals that there are indeed distinctive kinds of neuro-atypical autonomy that are widely mistaken for non-autonomy. This project argues for two propositions. First, that there is a kind of autonomy, with a distinctive shape and texture, available to bipolar agents. This is a variant sort of autonomy, but not a defective or deficient sort. It is the ideal of autonomy that it is worth bipolar agents striving for, given the range and intensity of experiences that they will have to confront. Whilst bipolar autonomy will look unlike more neurotypical kinds of autonomy, it continues to be owed recognition. The second proposition is that we should understand the ideal of autonomy to be both pluralist and highly context sensitive. Given the range of starting points from which agents will strive to an ideal of autonomy, there will be some variation in the ideals worth striving for. The variation in ideals will reflect the existential realities they are local to. Theory of autonomy must be adapted to recognise bipolar, and other neuro-atypical, kinds of autonomy, and to reflect this wider pluralism. These propositions will be argued for with careful attention to the experiences and agency of people living with bipolar, or related, disorders. Understanding the ways that manic or depressive episodes, and the shifts between them, alter and apply pressure to our agency will inform an account of the distinctively bipolar autonomy that can be built on top of it. (shrink)

A debate persists over how to distinguish manic states from non-manic ones (such as depressions). A lacuna exists amongst these efforts, where a specifically agentive account of mania would sit. An agentive account centers the manic person’s view of practical reasons, rationalizing their actions in the same way that sympathetic understandings rationalize the actions of more neurotypical agents. In this paper, I argue that mania restructures our agency by creating a pervasive sense of urgency. This urgency changes the kind of (...) handling that our practical reasons seem to call out for. Whilst this can make us less reliable as agents, I argue that this does not undermine the basic capacities on which personal autonomy is founded. The greater threat to manic agents’ autonomy is nonrecognition of this restructured agency, undermining autonomy in its social dimensions. Without an agentive account, we will fail to recognize distinctly manic agency when we see it, limiting our understanding of autonomy, and withholding recognition, fundamental to autonomy in its social dimensions, from manic agents. (shrink)

Abstract:Bipolar or related disorders (BoRD) present unique practical and existential problems for people who live with them. All agents experience changes in the things they care about over time. However people living with BoRD face drastic shifts in what seems valuable to them, which upset their longitudinal values (if, indeed, any stable longitudinal values are available in the first place). Navigating these evaluative high seas presents agents living with BoRD with a distinctive existential question, not shared by those on calmer (...) waters. I draw out two contrasting ways in which someone living with BoRD might seek to support their self-determination in these circumstances, by crafting appropriate self care and support regimes. The first strategy involves managing one’s affective episodes so that they do not interrupt one’s plans and long-term agency over time. The second involves a regimen that allows one the greatest degree of freedom in adapting to changes in one’s experiences of value. What distinguishes these sorts of self-determination is the scope at which they are predicated. Although both sorts of self-determination allow an individual to rule themselves, they alter the overall shape of one’s autonomy in quite different ways. (shrink)

The Patient Self Determination Act of 1991 brought much needed attention to the importance of advance care planning and surrogate decision-making. The purpose of this law is to ensure that a patient’s preferences for medical care are recognized and promoted, even if the patient loses decision-making capacity. In general, patients are presumed to have DMC. A patient’s DMC may come under question when distortions in thinking and understanding due to illness, delirium, depression or other psychiatric symptoms are identified or suspected. (...) Physicians and other healthcare professionals working in hospital settings where medical illness is frequently comorbid with depression, adjustment disorders, demoralization and suicidal ideation, can expect to encounter ethical tension when medically sick patients who are also depressed or suicidal request do not resuscitate orders. (shrink)

William Godfrey-Smith is now William Grey. It is agreed that the moral community can be justifiably extended to include sentient non-humans, however, it is claimed that it is possible to give up human chauvinism without adopting the ethic Godfrey-Smith advocates. Feinberg's interest principle is taken by Godfrey-Smith to be the most promising for demarcating the class of individuals to whom rights can be properly attributed. It is claimed that this principle does not force an extension of the class of rights-holders (...) beyond the class of sentient individuals, as claimed by Godfrey-Smith, to include individual trees, rainforests, soils and whole species. The crucial difference, it is claimed, is that sentient individuals but not plants are the subjects of experience. It is claimed that Godfrey-Smith has not provided sufficient argument to force an extension of the class of right-bearers in the way he advocates. Godfrey-Smith opposes the view that all values are grounded in human interest and concern, however, it is not necessary to accept his conclusion in order to argue against this position. Finally, it is not clear that he has produced an argument that shows there is no dependence between value and valuers analogous to the dependence between, say, lies and liars. (shrink)

No one theory of time is pursued in the essays of this volume, but a major theme that threads them together is Wolfson’s signature idea of the timeswerve as a linear circularity or a circular linearity, expressions that are meant to avoid the conventional split between the two temporal modalities of the line and the circle.

E. L. Grant Watson, an English field naturalist, zoologist, and one of England's best-loved nature writers, spent a lifetime trying to bring nature and...

Through an extensive examination of the conceptions of social justice that may be ascribed validly to Karl Marx's political thougtht, Elliot R. Pruzan analyzes the apparent conflict between Marx as value-neutral social scientist and as revolutionary. He suggests a resolution to this conflict through a carefully constructed presentation of Marx's theory of human nature and the ethical presuppositions of that theory. In so doing, Pruzan identifies those elements of Marx's political thought that warrant our continued serious consideration of it (...) as a genuine theory of politics, especially when compared with other more traditionally conceived forms of political thought. (shrink)

This piece raises a new challenge for Christian materialist accounts of human persons. Revisiting one of the perennial challenges for Christian materialism, explaining the metaphysical compatibility of resurrection and the life everlasting with materialist metaphysics, I argue that resuscitation phenomena reported in scripture undermine van Inwagen’s and Zimmerman’s attempts to reconcile resurrection and materialism. Although this challenge to Christian materialism is not insurmountable, it provides good reason to reject several of the most serious Christian materialist projects and offers a reason (...) for Christians to consider alternatives to materialism. (shrink)

This book offers a critical introduction to the work of American philosopher D. G. Leahy (1937-2014). Leahy's fundamental thinking can be characterized as an absolute creativity in which all creating is 'live' -- a happening occurring now that manifests a supersaturated polyontological actuality that is essentially created by the logic that characterizes it. Leahy leaves behind the categorial presuppositions of modern thought, eclipsing both Cartesian and Hegelian subjectivities and introducing instead an essentially new form of thinking founded in a nondual (...) logic of creation. The new thinking delineates the absolute unicity of existence as a creative interactivity beyond all traditional dichotomies (such as one vs. many, unity vs. plurality, identity vs. change): a fully "digitized" actuality that is nothing but newness, which inherently implies nothing but change. Through this new form of thinking, change itself is revealed to be the very essence of reality and mind. Any reader looking for a quantum leap beyond the thrall of modern and postmodern fixations is invited to hear and apprehend this new thinking that refuses to be conditioned by paradigms, categories, species, genera, walls, bridges, boundaries, or abstractions: an essentially free thinking that embodies creative novelty itself. (shrink)

Belonging together of the foreign -- Hermeneutic circularity: tradition as genuine repetition of futural past -- Inceptual thinking and nonsystematic atonality -- Heidegger's Seyn/Nichts and Kabbalistic Ein Sof -- Simsum, Lichtung, and bestowing refusal -- Autogenesis, nihilating leap, and otherness of the not-other -- Temporalizing and granting time-space -- Disclosive language: poiesis and apophatic occlusion of occlusion -- Ethnolinguistic enrootedness and invocation of historical destiny.

according to some interpreters of John Locke’s moral philosophy, there is an inconsistency between Locke’s adoption of hedonism and his commitment to a natural law view of ethics. Indeed, Locke is not fully explicit about the relationship between pleasure and pain and the natural law in the Essay concerning Human Understanding. But the thesis I defend in this paper is that the idea of convenientia, according to which God harmonizes the natural law with human nature, can be used to understand (...) how Locke synthesizes the hedonism he adopts in the 1670s, and ultimately expresses in Book II, chapter 20 of the Essay, with the natural law doctrine he maintains over the course of his lifetime. As I argue, God’s providential.. (shrink)

This paper sets the framework for a hybrid theory of Logic-Based Therapy and Psychoanalysis through an examination of Sigmund’s Freud’s theory of perfectionism.

LOCKE IS FREQUENTLY CALLED AN EMPIRICIST. HOWEVER, THE\nROLES OF REASON AND EXPERIENCE IN LOCKE'S EPISTEMOLOGY\nHAVE, THEREBY, BEEN OBSCURED. IN THIS PAPER, DIFFERENT\nSENSES OF "EMPIRICISM" AND "RATIONALISM" ARE DISTINGUISHED,\nAND RELEVANT PASSAGES FROM LOCKE'S WRITINGS ARE SCRUTINIZED\nFOR PURPOSES OF EXPLICATING HIS EPISTEMOLOGY. THROUGH THIS\nEXAMINATION, IT IS SEEN THAT LOCKE, LIKE KANT, SEEKS A\n"REASON-EXPERIENCE SYNTHESIS" AND THAT THE BLANKET LABEL\n"EMPIRICIST," AS APPLIED TO LOCKE, IS MOST UNFORTUNATE.

Isaac Newton affirms on several occasions that human understanding cannot reach the essence of bodies. The article seeks to answer the question of why we cannot reach their essence either through our reflection or our senses, which confines our cognition to their appearances. I argue that the answer to this problem lies in Newton’s theological voluntarism, which he fully developed for the first time and explicitly in relation to the problem of the nature of bodies in his manuscript De gravitatione. (...) Newton’s God could create beings similar to bodies, which display all their actions and exhibit all their phenomena, and yet they would not be bodies in their essential and metaphysical constitution. Newton’s theological voluntarism has other important epistemological consequences, such as God’s ability to freely change the laws of nature according to his will. (shrink)

The article focuses on Galileo's Letter to Castelli, 21 December 1613. The author analyzes Galileo's hermeneutical principles established in the first part of the letter and his literal interpretation of the passage from the Book of Joshua 10, 12-13, in Copernican terms, in the second part of the letter. Galileo appears to use the Bible as a scientific authority, supporting his Copernican views, and thus he seems to contradict his own hermeneutical principles. The author argues that Galileo's position is consistent, (...) especially if one takes into account the historical context of its genesis, that is, in the context of the constant, theologically-inspired attacks on Copernicus and Galileo and his commitment to the heliocentric world system and in the context of his newly-made telescopic observations and discoveries. (shrink)

This article first describes some of the chief contrasts between Judaism and American secularism in their underlying convictions about the business environment and the expectations which all involved in business can have of each other—namely, duties vs. rights,communitarianism vs. individualism, and ties to God and to the environment based on our inherent status as God’s creatures rather than on our pragmatic choice. Conservative Judaism’s methodology for plumbing the Jewish tradition for guidance is described and contrasted to those of Orthodox and (...) Reform Judaism.One example of how Conservative Judaism can inform us on a current matter is developed at some length—namely, privacy in the workplace. That section discusses (1) the reasons for protecting privacy; (2) protection from intrusion, including employer spying; (3) protection from disclosure of that intended to remain private; (4) individualistic vs. communitarian approaches to grounding the concern for privacy; and (5) contemporary implications for insuring privacy in business. (shrink)

Incarceration served as a primary apparatus by which abolition democracy was defeated after Reconstruction. Carceral institutions—such as the penitentiary, the convict-lease system, and the chain gang—functioned to demarcate the racial limits of citizenship and to impede equal political power. This article turns to W. E. B. Du Bois to argue that incarceration constrains democratic political equality. Turning to Du Bois’s treatment of crime and imprisonment in works including The Philadelphia Negro (1899), “The Spawn of Slavery” (1901), and The Souls of (...) Black Folk (1903), alongside archival material, I situate incarceration in Du Bois’s democratic thought. According to Du Bois, carceral institutions bounded ideas of full citizenship, fueled panic over Black “criminality,” fomented feelings of inferiority, and hampered the possibility for abolition democracy, a multiracial, multiclass movement committed to worker democracy and a future rid of slavery and subjugation. Du Bois shows us how carceral institutions run into tension with democratic ideals. (shrink)

The philosophical past, once a thing of the past, is with us again. I examine three recent positions about how to understand the philosophical past: the presentism of Richard Rorty, the traditionalism of Alasdair MacIntyre, and the interpretism of Charles Taylor. Rorty, MacIntyre, and Taylor all acknowledge a Hegelian influence upon their views; thus, I also explore Hegel's own view of the history of philosophy. Finally, I offer my own view that our relation to the past ought to be guided (...) by "recognizing" it. Although the concept of recognition is found in Hegel, I argue that Hegel as well as Rorty and MacIntyre end up conceiving of our relation to the past as one of appropriation. Recognition as I define it eschews such appropriation; rather, it consists in a "working through" of the past in a sense the paper specifies. (shrink)

The author argues that Newton’s distinction between absolute and relative motion, i.e. the refusal to define motion in relation to sensible things, in “Scholium on time, space, place and motion” from _Mathematical Principles of Natural Philosophy_, stems in great part from his critical stance towards Descartes’s philosophy of nature. This is apparent from the comparison of “Scholium”, in which Descartes is not mentioned at all, with Newton’s criticism of him in his manuscript _De gravitatione_. The positive results of Newton’s encounter (...) with Descartes’s theory of motion is almost completely identical to those of the “Scholium”: the definition of motion must concern the whole body and not just its surface; instead of “mutual translation”, it must include the force that is the cause of the physical motion; the motion of the bodies is uniform and straightforward, which can only be achieved within absolute space. As far as the theory of motion is concerned, Newton’s philosophical challenge was always Descartes. (shrink)

In this, his third book on modern ethics for JPS, Elliot Dorff focuses on personal ethics, Judaism's distinctive way of understanding human nature, our role in ...